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pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can decrease panobinostat stages by ~70% and bring about therapy failure.pentobarbital will decrease the extent or outcome of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pento